Unfortunately, we only treat patients in an early to mid-stage of ALS. The precise workflow is described in detail on the stem cell- specific pages of BMC, Secretome/Exosomes and PRP (as combination therapy).Īll therapies are divided into phases such as evaluation of the medical history (we analyze your current therapies and medical records), initial counseling and evaluation of potential, patient-individual benefit of a stem cell therapy (indication statement), preliminary examinations, diagnostics, consultation on all therapy options, preparation of an individual treatment plan including cost estimate, harvesting of tissue, production of the stem cell product, quality control of the product and application. What a Secretome/Exosome is and how they compare is explained on our overview page. This is especially advantageous for repeated stimulation of cell survival and regeneration in ALS. This enables us to produce 10-20 injection doses from one liposuction which can then be administered over a longer treatment period. The main advantage of MSEC is that in contrast to live stem cells which would loose their therapeutic potency, can be frozen without loss of exosomes. Worldwide, ANOVA is the first stem cell clinic to acquire legal permission form the responsible governmental authorities and therefore, offers high quality, safe and legally-controlled autologous (own) exosome-containing secretome. For more information, please feel free to contact us.Īs ALS is a chronic, so far not curable disease, we on-goingly treat patients with early to mid-stage ALS with MSEC (secretome, exosomes, EVs) of mesenchymal stem cells (MSC, AD-MSC, adipose-derived, fat-derived stem cells) which we harvest from the patients belly in a mini-liposuction (very brief and limited liposuction) under slight sedation. ANOVA offers this experimental and novel stem cell-based therapy patients with ALS. Stem Cell Secretome is the essence of stem cells, and can facilitate neuro-protection and recovery of neuro-motorial function. Our experience shows that Stem Cell Secretome is a promising, novel strategy that appears to be more effective and safer than the cells themselves. Many current pre-clinical studies suggest that stem cell transplantation has the best effect when aimed towards protecting, rather than replacing or repairing the motor neurons of ALS patients. A more recent study, by the same group, however, confirmed that MSC transplantation into the spinal cord of ALS patients is not only safe, but might also serve as a treatment option for future cell-based clinical trials for the treatment of ALS. demonstrated that the procedure of ex vivo expansion of autologous Mesenchymal Stem Cells (MSCs) and transplantation into the spinal cord of humans was safe and well tolerated by ALS patients. Stem Cell-based therapies may be the answer. ALS is not a typical autoimmune disorder, since autoimmune and inflammatory abnormalities are not the cause of the disease, even though they influence its progression. Often, the origin of the disease is unknown. This results in a severe motor dysfunction muscles become atrophic due to the lack of nerve stimulation. It is a complex disease which involves the activation of several cellular pathways in both neurons and glial cells.
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